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Find A Clinical Trial

Disease Type: Breast

Trial ID 20284
Sponsor ID Seattle Genetics, Inc.

A Single Arm, Open Label Phase 2 Study of Tucatinib in Combination with Trastuzumab Deruxtecan in Subjects with Previously Treated Unresectable Locally-Advanced or Metastatic HER2+ Breast Cancer (SGNTUC-025)

Principal Investigator
Anne Favret, MD
1 Location
Trial ID 19049
Sponsor ID Genentech, Inc.

The main purpose of this study is to learn if the usual chemotherapy given before surgery (neoadjuvant therapy) for breast cancer plus the experimental drug, atezolizumab, is better than the usual chemotherapy plus a placebo. (A placebo is a drug that looks like the study drug but contains no medication.) The usual chemotherapy in this…

Principal Investigator
Anne Favret, MD
5 Locations
Trial ID 19058
Sponsor ID

CLEE011O12301C (TRIO033): A phase III, multicenter, randomized, open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]: NATALEE).

Principal Investigator
Alexander I Spira, MD, PhD, FACP
1 Location
Trial ID 19054
Sponsor ID

Randomized, double-blind, phase 3 study of tucatinib or placebo in combination with ado-trastuzumab emtansine (T-DM1) for subjects with unresectable locally-advanced or metastatic HER2+ breast cancer (SGNTUC-016)

Principal Investigator
Christina Brzezniak, DO
5 Locations
Trial ID DS8201-A-U303
Sponsor ID DS8201-A-U303

A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED TRIAL OF DS-8201A, AN ANTI-HER2-ANTIBODY DRUG CONJUGATE (ADC), VERSUS TREATMENT OF PHYSICIAN’S CHOICE FOR HER2LOW, UNRESECTABLE AND/OR METASTATIC BREAST CANCER SUBJECTS

Principal Investigator
Neelima Denduluri, MD, FASCO
1 Location
Trial ID 14059
Sponsor ID

Phase I/II trial of Ibrutinib plus Trastuzumab in HER2-amplified Metastatic Breast Cancer

Principal Investigator
Alexander I Spira, MD, PhD, FACP
1 Location
Trial ID 18282
Sponsor ID

Phase 3 Study of Sacituzumab Govitecan (IMMU-132) Versus Treatment of Physician’s Choice (TPC) in subjects with Hormonal Receptor-Positive (HR+) Human Epidermal Growth Factor Receptor 2 (HER2) Negative Metastatic Breast Cancer (MBC) who have failed at least two prior chemotherapy regimens (IMMU-132-09)

Principal Investigator
Christina Brzezniak, DO
5 Locations
Trial ID DS8201-A-U301
Sponsor ID DS8201-A-U301

A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF DS-8201A (TRASTUZUMAB DERUXTECAN), AN ANTI-HER2-ANTIBODY DRUG CONJUGATE, VERSUS TREATMENT OF INVESTIGATOR’S CHOICE FOR HER2-POSITIVE, UNRESECTABLE AND/OR METASTATIC BREAST CANCER SUBJECTS PRETREATED WITH PRIOR STANDARD OF CARE HER2 THERAPIES, INCLUDING T-DM1

Principal Investigator
Neelima Denduluri, MD, FASCO
1 Location
Trial ID 18232
Sponsor ID

(AB928CSP0002) A Phase 1/1b Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants with Breast or Gynecologic Malignancies

Principal Investigator
Alexander I Spira, MD, PhD, FACP
1 Location
Trial ID SIDE-OUT 3
Sponsor ID

Utilizing Multiomic Advanced Diagnostics to Identify Palbociclib Response Predictors and a Post-treatment Multiomic Signature for Patients with ER+/HER2- Metastatic Breast Cancer

Principal Investigator
Neelima Denduluri, MD, FASCO
6 Locations