Temporary Phone Service Interruption – Friday Evening. We will be upgrading our phone system Friday beginning at 5:30 PM. After-hours calls in the early part of the evening may not connect until service is restored later that night. For medical emergencies, please call 9-1-1. Thank you for your patience and understanding.
The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. Check for active clinical trials using this agent. (NCI Thesaurus)
Related Posts
Recent Posts
