Alexander I. Spira, MD, PhD, FACP

VCS Physicians

Alexander I. Spira, MD, PhD, FACP Headshot

Getting a diagnosis of cancer is the most challenging thing any patient and family will have to go through. My job is to provide the most comprehensive options for patients, with state-of-the-art care and compassion.

Work and Credentials:

Primary Location

Fairfax Office

Position

Medical Oncologist

Board Certification

Medical Oncology and Internal Medicine

Fellowship

Johns Hopkins Hospital, Medical Oncology

Internship

Hospital of the University of Pennsylvania

Residency

Hospital of the University of Pennsylvania

Medical School

New York University School of Medicine

College

Harvard University

Alexander I Spira, MD, PhD, FACP

Co-Director, VCS Research Institute, Director, Thoracic and Phase I Program, Clinical Assistant Professor, Johns Hopkins

Dr. Alexander Spira earned his medical degree from the New York University School of Medicine. He then went on to complete his internship and residency at the Hospital of the University of Pennsylvania, and his medical oncology fellowship at Johns Hopkins Hospital. During his training, Dr. Spira was granted many awards and honors, and he completed several specialized fellowship programs. Among these honors were the National Institutes of Health Medical Scientist Training Program Fellowship (1990-1997), Merck Corporation Scholarship (1995-1995), Pediatric AIDS Foundation Fellowship (1993- 1995) and Harvard University Scholarship (1987-1990). Dr. Spira has also received his PhD from the New York School of Arts and Sciences.

As Director of the Virginia Cancer Specialists (VCS) Research Institute and the Phase I Trial Program, Dr. Spira is actively involved in advancing medicine and offering targeted treatment options for patients. Although his research interests are numerous, Dr. Spira particularly enjoys studying immunotherapy, personalized medicine, GI, thoracic and lung cancer and sarcomas. Dr. Spira is also Co-Chair of the USOncology Thoracic Oncology Committee, Chair of the USOncology Research Executive Committee, and member of the USOncology National Policy Board Executive Committee. Dr. Spira is a faculty member at Johns Hopkins School of Medicine, and serves as Assistant Professor of Oncology.

Throughout his career, Dr. Spira has been recognized as a Top Doctor in Northern Virginia Magazine and Washingtonian magazine for multiple years. In 2014, he received the prestigious “Castle Connolly America’s Top Doctor” award. In his spare time, Dr. Spira enjoys spending time with his family, coaching children’s sports, cycling, and cheering on his favorite New York sports teams.


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Physician Videos:

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Physician Reviews:

RateMDs Reviewer
RateMDs Reviewer
2021-05-20 00:00:00
RateMDs Reviewer

Dr Spira is probably one of the best oncologists. His runs so many clinical trials and extremely knowledgeable. That really shows how passionate he is in finding effective treatments for cancer patients. I am very lucky to have him as my oncologist.

RateMDs Reviewer
RateMDs Reviewer
2020-04-15 00:00:00
RateMDs Reviewer

Great job: knowledgeable, informative, and a human touch,(apposed to robotic). He and his staff are outstanding.

RateMDs Reviewer
RateMDs Reviewer
2020-04-15 00:00:00
RateMDs Reviewer

Dr Alex Spira is "fully engaged & committed", a truly Top Notch Medical Professional at Virginia Cancer Specialists (VCS). He is well prepared, able to communicate in a caring but being respectful to his Patients, while building "trust" to improve and advance the health & life of the VCS Patients ! Plus, based on our recent VCS visits, Dr. Spira's and the VCS Teams project a true desire to provide the "Best Quality Care for Patients". On that note, I have personally noted, Dr Spira's "day to day" interactions with his Dr.'s, RN Nurses, VCS Teams and Patients. Dr Alex Spira demonstrates "Leadership & Quality Care to Patients", by building the VCS Medical "bench strength" by ensuring everyone is cross trained to ensure quality care to Patients from all the VCS Team of Specialist, that's "Team Work" ! My Care Giver (my wife) and I are proud to be a Patent's and be part of VCS, at this time of my life, God Bless, Thank You to all Medical "Professionals" at VCS !

RateMDs Reviewer
RateMDs Reviewer
2020-10-20 00:00:00
RateMDs Reviewer

Dr. Spira was professional, knowledgeable and informative. Both the Doctor and his staff were approachable, engaging and friendly. Both my wife and I found our experience with Dr. Spira to be quite positive.

RateMDs Reviewer
RateMDs Reviewer
2021-02-24 00:00:00
RateMDs Reviewer

Dr Spira has been treating my cancer for eight years. He is competent and caring. I am always happy to see him, and him me. He is a brilliant scientist who is on top of his field.

RateMDs Reviewer
RateMDs Reviewer
2021-03-01 00:00:00
RateMDs Reviewer

Dr. Spira and all his staff at VCS are first rate as they really try their best in providing the best healthcare possible. Dr. Spira is a most distinguished and commendable oncologist. He is open to patient"s questions all the time and provide answers that are comforting and easily understood. I would highly recommend this facility.

Physician Publications

July 13, 2022

Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma

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June 3, 2022

ASCO 2022 | KRYSTAL-1: activity and safety of adagrasib in patients with advanced/metastatic KRASG12Cm NSCLC

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June 3, 2022

Adagrasib Induces Promising Efficacy, Deep Responses in KRAS G12C NSCLC

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More Publications by Alexander I. Spira, MD, PhD, FACP

June 3, 2022

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation

Read More
June 3, 2022

KRAS Inhibitor Shrinks Tumors in Over 40% of NSCLC Patients

Read More
June 3, 2022

Dr. Spira on the Potential Role of Adagrasib in NSCLC

Read More
April 8, 2022

Rubius Therapeutics Reports Updated Clinical Data at AACR from the Ongoing Monotherapy Phase 1 Arm of the Phase 1/2 Clinical Trial of RTX-240 in Advanced Solid Tumors Demonstrating Single-Agent Activity and Favorable Tolerability

Read More
March 15, 2022

Has the Enemy "MET" Its Match? Subgroup Analysis Results from VISION Study

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December 1, 2021

A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer

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December 1, 2021

Phase II, Randomized Study of Spartalizumab (PDR001), an Anti-PD-1 Antibody, versus Chemotherapy in Patients with Recurrent/Metastatic Nasopharyngeal Cancer

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October 18, 2021

The Effects of HER2 Alterations in EGFR Mutant Non-small Cell Lung Cancer

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September 13, 2021

Characterization of KRAS Mutation Subtypes in Non-small Cell Lung Cancer

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August 2, 2021

Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study

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July 1, 2021

First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

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July 1, 2021

A Phase Ib/II Study of Pepinemab in Combination with Avelumab in Advanced Non-Small Cell Lung Cancer

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May 24, 2021

Clinical outcomes and resource utilization after surgical resection with curative intent among patients with non-small cell lung cancer treated with adjuvant therapies in a community oncology setting: A real-world retrospective observational study

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May 3, 2021

Multicenter, Open-Label, Phase I Study of DSP-7888 Dosing Emulsion in Patients with Advanced Malignancies

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May 1, 2021

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Laboratory Reference Ranges and Testing Intervals Work Group

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February 25, 2021

Activity and Safety of Mobocertinib (TAK-788) in Previously Treated Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations from a Phase I/II Trial

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January 29, 2021

Datopotamab deruxtecan and Enhertu show promising early clinical activity in patients with advanced non-small cell lung cancer

Read More
January 29, 2021

Datopotamab Deruxtecan Elicits Early Antitumor Activity in Relapsed/Refractory Metastatic NSCLC

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December 26, 2020

Model Informed Dosing Regimen and Phase I Results of the Anti-PD-1 Antibody Budigalimab (ABBV-181)

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September 1, 2020

Reducing Uninformative IND Safety Reports: A List of Serious Adverse Events anticipated to Occur in Patients with Lung Cance

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August 11, 2020

Brigatinib Versus Crizotinib in Advanced ALK Inhibitor–Naive ALK-Positive Non–Small Cell Lung Cancer: Second Interim Analysis of the Phase III ALTA-1L Trial

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June 7, 2020

Camidanlumab Tesirine, an Antibody-Drug Conjugate, in Relapsed/Refractory CD25-positive Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia: A Phase I Study

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April 7, 2020

Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue SarcomasThe ANNOUNCE Randomized Clinical Trial

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March 21, 2020

Outcomes with durvalumab by tumour PD-L1 expression in unresectable, stage III non-small-cell lung cancer in the PACIFIC trial

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October 1, 2019

A review of canakinumab and its therapeutic potential for non-small cell lung cancer.

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August 1, 2019

Detection of NRG1 Gene Fusions in Solid Tumors.

Read More
August 1, 2019

Multicenter Phase I Study of Erdafitinib (JNJ-42756493), Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients with Advanced or Refractory Solid Tumors.

Read More
September 25, 2018

Brigatinib versus Crizotinib in ALK-Positive Non–Small-Cell Lung Cancer

Read More
March 9, 2016

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

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September 14, 2015

Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial

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June 3, 2013

START: A phase III study of L-BLP25 cancer immunotherapy for unresectable stage III non-small cell lung cancer.

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February 1, 2013

Cabozantinib in Patients With Advanced Prostate Cancer: Results of a Phase II Randomized Discontinuation Trial

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January 2, 2013

Expert Insight: Adjuvant Therapy Fails for High-Risk Soft Tissue Sarcoma

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June 1, 2012

Phase II study of two eribulin regimens in combination with erlotinib in patients (pts) with previously treated advanced non-small cell lung cancer

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April 16, 2012

Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non-Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy

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January 1, 2012

Clinical trial design in the age of molecular profiling.

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September 8, 2011

A phase II study of eribulin mesylate (E7389) in patients with advanced, previously treated non-small-cell lung cancer.

Read More
June 1, 2011

Results of a phase II study of single-agent sunitinib in elderly non-small cell lung cancer patients

Read More
June 1, 2011

Clinical outcome of single agent volasertib (BI 6727) as second-line treatment of patients (pts) with advanced or metastatic urothelial cancer (UC).

Read More
June 1, 2011

Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial.

Read More
December 4, 2010

Serotonin Dysregulation Correlates with Both Bone and Active Disease In Multiple Myeloma.

Read More
December 1, 2010

Phase I Trial of Oxaliplatin, Infusional 5-Fluorouracil, and Leucovorin (FOLFOX4) With Erlotinib and Bevacizumab in Colorectal Cancer.

Read More
December 3, 2009

Use of an ex vivo multiplexed signal pathway inhibitor treatment to reveal sensitivity of myeloma and nonmyeloma bone marrow cell populations.

Read More
December 1, 2009

Phase II trial of nanoparticle albumin-bound paclitaxel, carboplatin, and bevacizumab in first-line patients with advanced nonsquamous non-small cell lung cancer.

Read More
January 22, 2004

Multidisciplinary Management of Lung Cancer

Read More
January 1, 2002

The use of Chemotherapy in Soft Tissue Sarcomas

Read More

Clinical Trials (176)

Clinical Trial 516-014

A Multicenter, Open-Label, Extension Study of the Safety and Tolerability of Sitravatinib Alone or in Combination with Other Anticancer Therapies in Patients with Advanced or Metastatic Solid Malignancies


Clinical Trial NAV-1104

Phase 1 Study of SHP2 Inhibitor BBP-398 in Combination with the Programmed Death Receptor-1 Blocking Antibody Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer with a KRAS Mutation


Clinical Trial JBI-802-101

A First-in-Human, Open-Label, Dose Escalation and Expansion Study of Orally Administered JBI-802 in Patients with Advanced Solid Tumors


Clinical Trial FURMO

A Phase 1b Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Antitumor Activity of Furmonertinib in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer with Activating EGFR or HER2 Mutations Including Exon 20 Insertion Mutations


Clinical Trial DR-01-ONC-001

A Multicenter, Open-Label, First-in-Human, Multiple Expansion Cohort, Phase 1/2 Study to Evaluate the Safety and Efficacy of DR-01 in Adult Subjects with Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas


Clinical Trial ASP3082

A Phase I Study of ASP3082 in Participants with Previously Treated Locally Advanced or Metastatic Solid Tumor Malignancies with KRAS G12D

All Clinical Trials for Alexander I. Spira, MD, PhD, FACP

Clinical Trial 516-014

A Multicenter, Open-Label, Extension Study of the Safety and Tolerability of Sitravatinib Alone or in Combination with Other Anticancer Therapies in Patients with Advanced or Metastatic Solid Malignancies

Locations:

Fairfax Office


Clinical Trial NAV-1104

Phase 1 Study of SHP2 Inhibitor BBP-398 in Combination with the Programmed Death Receptor-1 Blocking Antibody Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer with a KRAS Mutation

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05375084

ClinicalTrials.gov Link:

Click Here


Clinical Trial JBI-802-101

A First-in-Human, Open-Label, Dose Escalation and Expansion Study of Orally Administered JBI-802 in Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05268666

ClinicalTrials.gov Link:

Click Here


Clinical Trial FURMO

A Phase 1b Dose Escalation and Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Antitumor Activity of Furmonertinib in Patients with Advanced or Metastatic Non-Small Cell Lung Cancer with Activating EGFR or HER2 Mutations Including Exon 20 Insertion Mutations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05364073

ClinicalTrials.gov Link:

Click Here


Clinical Trial DR-01-ONC-001

A Multicenter, Open-Label, First-in-Human, Multiple Expansion Cohort, Phase 1/2 Study to Evaluate the Safety and Efficacy of DR-01 in Adult Subjects with Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05475925

ClinicalTrials.gov Link:

Click Here


Clinical Trial ASP3082

A Phase I Study of ASP3082 in Participants with Previously Treated Locally Advanced or Metastatic Solid Tumor Malignancies with KRAS G12D

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05382559

ClinicalTrials.gov Link:

Click Here


Clinical Trial SGN-ALPV-001

A Phase 1 Study of SGN-ALPV in Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05229900

ClinicalTrials.gov Link:

Click Here


Clinical Trial VS-6766-204

A Phase 1/2 Study of VS-6766 in Combination with Adagrasib in Patients with KRAS G12C Mutant Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05375994

ClinicalTrials.gov Link:

Click Here


Clinical Trial ALKS 4230-003

Clinical and Immunologic Activity of Nemvaleukin Alfa With a Less Frequent IV Dosing Schedule as Monotherapy and in Combination with Pembrolizumab and Impact on Tumor Microenvironment in Solid Tumor Patients (ARTISTRY-3)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04592653

ClinicalTrials.gov Link:

Click Here


Clinical Trial RMC-6291-001

Phase 1/1b, Multicenter, Open-Label, Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects with Advanced KRAS G12C Mutant Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05462717

ClinicalTrials.gov Link:

Click Here


Clinical Trial H002-101

A Phase 1/2a, Open-Label, Dose-Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Preliminary Anti-Tumor Activity of H002 in Patients with Active Epidermal Growth Factor Receptor Mutation Locally Advanced or Metastatic Non-Small Lung Cancer

Locations:

Fairfax Office


Clinical Trial IO-202-CL-002

A Phase 1, Multicenter, Open-Label, Dose-Escalation, and Dose Expansion Study of IO-202 in Combination with Pembrolizumab in Subjects with Advanced, Relapsed, or Refractory Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05309187

ClinicalTrials.gov Link:

Click Here


Clinical Trial ASN004

An Open Label, Multicenter, Dose-Finding Clinical Phase 1 Study of ASN004 to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy with Advanced Malignant Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04410224

ClinicalTrials.gov Link:

Click Here


Clinical Trial XTX101

A First-in-Human, Multicenter, Phase 1/2, Open-Label Study of XTX101 Monotherapy and XTX101 and Pembrolizumab Combination Therapy in Patients with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04896697

ClinicalTrials.gov Link:

Click Here


Clinical Trial NUV-868

Phase 1/2 Safety and Efficacy Study of NUV-868 as Monotherapy and in Combination with Olaparib or Enzalutamide in Adult Patients with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05252390

ClinicalTrials.gov Link:

Click Here


Clinical Trial PEEL-224

An Early Phase Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of PEEL-224 in Patients with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05329103

ClinicalTrials.gov Link:

Click Here


Clinical Trial ERAS-007-04

A Phase 1b/2 Master Protocol of Agents Targeting the Mitogen-Activated Protein Kinase Pathway in Patients with Hematologic Malignancies (HERKULES-4).

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05279859

ClinicalTrials.gov Link:

Click Here


Clinical Trial AZD8701

A Phase 1 First-in-Human Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of AZD8701 Administered Intravenously as Monotherapy and in Combination with Durvalumab (MEDI4736) in Participants with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04504669

ClinicalTrials.gov Link:

Click Here


Clinical Trial SPX-101

A Phase 1, Open-Label Study to Evaluate Safety, Tolerability, Pharmacokinetics and Efficacy of an Anti-Claudin 18.2 Antibody SPX-101 in Patients with Advanced or Refractory Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05231733

ClinicalTrials.gov Link:

Click Here


Clinical Trial RMC-6236

Phase 1/1b Multicenter Open-Label Study of RMC-6236 in Subjects with Advanced Solid Tumors Harboring Specific Mutations in KRAS.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05379985

ClinicalTrials.gov Link:

Click Here


Clinical Trial BNT142-01

First-in-Human, Open-Label, Mulitcenter, Phase 1/2a, Dose Escalation Trial with Expansion Cohorts to Evaluate Safety and Preliminary Efficacy of BNT142 in Patients with CLDN6-Positive Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05262530

ClinicalTrials.gov Link:

Click Here


Clinical Trial XMT-1660

A Phase 1b, First-in-Human, Dose Escalation and Expansion, Multicenter Study of XMT-1660 in Participants with Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05377996

ClinicalTrials.gov Link:

Click Here


Clinical Trial DZ2019E0001

A Phase 1/2, Open-Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics and Anti-tumor Efficacy of DZD9008 in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with EGFR or HER2 mutation

ClinicalTrials.gov ID:

NCT03974022

ClinicalTrials.gov Link:

Click Here


Clinical Trial 21498

A Phase 1/2 Study of VS-6766 in Combination with Sotorasib in Patients with KRAS G12C mutant Non-Small Cell Lung Cancer (NSCLC) (RAMP 203)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05074810

ClinicalTrials.gov Link:

Click Here


Clinical Trial 21308

A Phase 1/2 Dose-Escalation and Dose-Expansion Study of ZN‑c3 in Combination with Niraparib in Subjects with Platinum-Resistant Ovarian Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05198804

ClinicalTrials.gov Link:

Click Here


Clinical Trial 21239

A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in Combination with Platinum-Based Chemotherapy Compared with Platinum-Based Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer After Osimertinib Failure

ClinicalTrials.gov ID:

NCT04988295

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20388

A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib in Combination with Pembrolizumab in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC) With KRAS p.G12C Mutation (CodeBreak 101 Subprotocol I)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20386

A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib in Subjects with Advanced Non-small Cell Lung Cancer (NSCLC) with KRAS p.G12C Mutation with Brain Metastases (CodeBreak 101 Subprotocol G)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20382

A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib in Combination with Palbociclib in Subjects with Advanced Solid Tumors with KRAS p.G12C mutation (CodeBreak 101 Subprotocol J)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

Click Here


Clinical Trial OMS-I141

A PHASE 2, MULTI-COHORT, OPEN-LABEL STUDY OF INTRATUMORAL TAVOKINOGENE TELSEPLASMID PLUS ELECTROPORATION IN COMBINATION WITH INTRAVENOUS EMBROLIZUMAB THERAPY WITH OR WITHOUT CHEMOTHERAPY IN PATIENTS WITH INOPERABLE LOCALLY ADVANCED OR METASTATIC TRIPLE NEGATIVE BREAST CANCER

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03567720

ClinicalTrials.gov Link:

Click Here


Clinical Trial DS1062-A-U104

A Phase 1b, Multicenter, 2-Part, Open-Label Study of Datopotamab Deruxtecan (Dato-DXd) in Combination with Durvalumab with or without Platinum Chemotherapy in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer (Tropion-Lung04) (Phase 1b Study of Dato-DXd in Combination with Durvalumab with or without Platinum Chemotherapy in Advanced or Metastatic Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04612751

ClinicalTrials.gov Link:

Click Here


Clinical Trial D967YC00001

A Phase Ib Multicenter, Open-label Dose-escalation Study to Evaluate the Safety and Tolerability of Trastuzumab Deruxtecan (T-DXd) and Durvalumab in Combination with Cisplatin, Carboplatin or Pemetrexed in First-line Treatment of Patients with Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) and Human Epidermal Growth Factor Receptor 2 Overexpression (HER2+)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04686305

ClinicalTrials.gov Link:

Click Here


Clinical Trial 47MAB-ADVCA-101

A Phase 1, Open-Label, Dose-Escalation Study of the Safety and Efficacy of STI-6643, an Anti-CD47 Human Monoclonal Antibody, in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04900519

ClinicalTrials.gov Link:

Click Here


Clinical Trial GO-010

A Phase 2/3, Randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination with Immune Checkpoint Blockade for Patients with Metastatic Colorectal Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05141721

ClinicalTrials.gov Link:

Click Here


Clinical Trial ERAS-007-02

Phase 1b/2, Open-Label, Multicenter Study of ERAS-007 in Combination with Other Anti-Cancer Therapies in Patients with Advanced Non-Small-Cell Lung Cancer (HERKULES-2)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04959981

ClinicalTrials.gov Link:

Click Here


Clinical Trial BT7480-100

Phase 1/2 Study of the Safety, Pharmacokinetics, and Preliminary Clinical Activity of BT7480 in Patients With Nectin-4 Associated Advanced Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05163041

ClinicalTrials.gov Link:

Click Here


Clinical Trial RBS2418

A First-in-Human, Phase 1a/b Dose Escalation and Expansion Study to Evaluate RBS2418 as Monotherapy and in Combination with Pembrolizuamab in Subjects with Advanced Unresectable, Recurrent Metastatic Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05270213

ClinicalTrials.gov Link:

Click Here


Clinical Trial BBP-398

A Phase 1 Study of the SHP2 Inhibitor BBP-398 in Combination with the Programmed Death Receptor-1 Blocking Antibody Nivolumab in Patients with Advanced Non-Small Cell Lung Cancer with a KRAS Mutation

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04528836

ClinicalTrials.gov Link:

Click Here


Clinical Trial BIO-106

A Phase 1/2 Study of BIO-106 as Monotherapy or in Combination with Pembrolizumab in Patients with Advanced Cancers (Starbridge-1)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05320588

ClinicalTrials.gov Link:

Click Here


Clinical Trial CF33-hNIS

A Phase 1, Dose Escalation, Safety, and Tolerability Study of VAXINIA (CF33-hNIS), Administered Intratumorally or Intravenously as a Monotherapy or in Combination with Pembrolizumab in Adult Patients with Metastatic or Advanced Solid Tumors

Locations:

Fairfax Office


Clinical Trial TNG908-C101

A Phase 1/2, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, and Preliminary Anti-Tumor Activity of TNG908 in Patients with MTAP-Deleted Advanced or Metatstatic Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05275478

ClinicalTrials.gov Link:

Click Here


Clinical Trial PRT2527-01

A Phase 1, Open-Label, Multicenter, Dose Escalation Study of PRT2527 in Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05159518

ClinicalTrials.gov Link:

Click Here


Clinical Trial AN4005

An Open-Label, Multicenter, Phase 1 Study of AN4005 in Patients with Advanced Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04999384

ClinicalTrials.gov Link:

Click Here


Clinical Trial NUV-422-04

A Phase 1b/2 Safety and Efficacy Study of NUV-422 in Combination with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05191017

ClinicalTrials.gov Link:

Click Here


Clinical Trial NUV-422-03

Randomized, Non-Comparative Phase 1/2 Study of NUV-422 in Combination with Fulvestrant in Patients with Hormone Receptor-Positive Epidermal Growth Factor Receptor2-Negative (HR+ HER2-) Advanced Breast Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05191004

ClinicalTrials.gov Link:

Click Here


Clinical Trial SET-101

A Phase 1/1b, Open-Label Multi Center Two Part Study of SETD2 Inhibitor EZM414 in Subjects with Relapsed/Refractory Multiple Myeloma and Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05121103

ClinicalTrials.gov Link:

Click Here


Clinical Trial PY314-1-101

A Phase 1a/1b Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PY314 as a Single Agent and in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04691375

ClinicalTrials.gov Link:

Click Here


Clinical Trial BDTX-1535

A Phase 1 Study to Assess BDTX-1535, an Oral EGFR Inhibitor, in Patients with Glioblastoma or Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05256290

ClinicalTrials.gov Link:

Click Here


Clinical Trial BLU-451-1

A Phase 1/2 Study of BLU-451 in Advanced Cancers with EGFR Exon 20 Insertion Mutations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05241873

ClinicalTrials.gov Link:

Click Here


Clinical Trial INBRX-209

A Randomized, Blinded, Placebo-Controlled, Phase 2 Study of INBRX-109 in Unrsectable or Metastatic Conventional Chondrosarcoma

ClinicalTrials.gov ID:

NCT04950075

ClinicalTrials.gov Link:

Click Here


Clinical Trial CLN-619-001

A Phase 1 Dose Escalation Study to Investigate the Safety, Efficacy, Pharmacokinetics, and Pharmacodynamic Activity of CLN-619 (Anti-MICA/MICB Antibody) Alone and in Combination with Pembrolizumab in Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05117476

ClinicalTrials.gov Link:

Click Here


Clinical Trial Onc-392-001

Safety, Pharmacokinetics, and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC: An Open Label Phase 1A/1B Study

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04140526

ClinicalTrials.gov Link:

Click Here


Clinical Trial BB1701

A First-in-Human, Open Label, Multiple Dose, Dose Escalation, and Cohort Expansion Phase I Study to Investigate the Safety, Tolerablity, Pharmacokinetics and Antitumor Activity of BB-1701 in Patients with Locally Advanced/Metastatic HER2 Expressing Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04257110

ClinicalTrials.gov Link:

Click Here


Clinical Trial D9077C00001

A Phase 2 Open-Label, Multicenter Randomized Study of Neoadjuvant and Adjuvant Treatment in Patients with Resectable, Early-Stage (II-IIIA) NSCLC

ClinicalTrials.gov ID:

NCT05061550

ClinicalTrials.gov Link:

Click Here


Clinical Trial CINC280AUS12

A Phase 2 Trial of Neoadjuvant and Adjuvant Capmatinib in Participants with Stages IB-IIIA, N2, and Selected IIIB (T3N2 or T4N2) NSCLC with MET Exon 14 Skipping Mutation or High MET Amplification

ClinicalTrials.gov ID:

NCT04926831

ClinicalTrials.gov Link:

Click Here


Clinical Trial USOR 21320

A Phase 1/2 Open-Label Escalation and Clinical Response Study of Quaratusugene Ozeplasmid in Combination with Osimertinib in Patients with Advanced, EGFR-Mutated, Metastatic NSCLC Who Have Progressed After Treatment with Osimertinib

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04486833

ClinicalTrials.gov Link:

Click Here


Clinical Trial TTI-621-03

A Phase 1/2 Study of TTI-621 in Combination with Doxorubacin in Patients with Unresectable or Metastatic High-Grade Leiomyosarcoma

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04996004

ClinicalTrials.gov Link:

Click Here


Clinical Trial USOR 21321

A Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults with Recurrent or Refractory Gliomas and Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04541225

ClinicalTrials.gov Link:

Click Here


Clinical Trial USOR 21281

A Phase 1b, Open-Label, Dose Escalation, Dose Expansion Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Orally Administered SM08502 Combined with Hormonal Therapy or Chemotherapy in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05084859

ClinicalTrials.gov Link:

Click Here


Clinical Trial INBRX105

An Open-Label, Multicenter, First-in-Human Dose Escalation, Phase 1 Study of INBRX-105 and INBRX-105 in Combination with Pembrolizumab in Patients with Locally Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03809624

ClinicalTrials.gov Link:

Click Here


Clinical Trial D910GC00001

A Randomized, Double Blind, Placebo-Controlled, Phase III Study of Neoadjuvant-Adjuvant Durvalumab and FLOT Chemotherapy in Patients with Resectable Gastric and GE Junction Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04592913

ClinicalTrials.gov Link:

Click Here


Clinical Trial HFB-301001-01

A Dose Escalation Study of HFB301001 (OX40 Agonist Antibody) in Adult Patients with Advanced Solid Tumors

Locations:

Fairfax Office


Clinical Trial ASP1570

A Phase 1 Study of ASP1570 in Participants with Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05083481

ClinicalTrials.gov Link:

Click Here


Clinical Trial ASP7517

A Phase 1/2, Open-Label Study Investigating the Safety, Tolerability and Efficacy of ASP7517 as a Single Agent and in Combination with Pembrolizumab in Patients with Advanced Solid Tumors Known to Express WT1 Antigen

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04837196

ClinicalTrials.gov Link:

Click Here


Clinical Trial PRJ1-3024

A Phase 1, First-in-Human, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of PRJ1-3024 in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05159700

ClinicalTrials.gov Link:

Click Here


Clinical Trial ES002023-1001

An Open-Label, Mulitcenter, First-in-Human, Dose Escalation, Phase 1 Study of ES002023 in Patients with Locally Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05075564

ClinicalTrials.gov Link:

Click Here


Clinical Trial IMM2902-101

A Phase 1, Open-Label, Multicenter, Dose Escalation Study Evaluating the Safety, Tolerability, and Preliminary Efficacy of IMM2902 in Patients with HER2-Expressing Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05076591

ClinicalTrials.gov Link:

Click Here


Clinical Trial M21-404

A Phase 1 First-in-Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV-400 in Adult Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05029882

ClinicalTrials.gov Link:

Click Here


Clinical Trial ZB131-101

A Phase 1/2, First-in-Human, Open-Label, Dose Escalation Study of Cancer-Specific Plectin (CSP)-Targeting Functional Antibody in Solid Tumors That Are Likley to Express CSP

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05074472

ClinicalTrials.gov Link:

Click Here


Clinical Trial HFB200301-01

A Phase 1, Open-Label, Multi-Center, Dose Escalation and expansion study of HFB200301 (TNFR2 Agonist Antibody) in Adult Patients with Advanced Solid Tumors

Locations:

Fairfax Office


Clinical Trial HBI-2376-101

A Phase 1, Open-Label, Dose Escalation of HBI-2376 in Patients with Advanced Malignant Solid Tumors Harboring KRAS or EGFR Mutations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05163028

ClinicalTrials.gov Link:

Click Here


Clinical Trial NVL-520-01

A Phase 1/2 Study of the Highly Selective ROS1 Inhibitor NVL-520 in Patients with Advanced NSCLC and other Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05118789

ClinicalTrials.gov Link:

Click Here


Clinical Trial CTIV1708

A Phase 1/2 Open-Label, Dose Escalation and Expansion Study of the Safety and Tolerability of T3011 when Administered via Intratumoral Injection as a Single Agent and in Combination with Intravenous Pembrolizumab in Participants with Advanced or Metastatic Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04780217

ClinicalTrials.gov Link:

Click Here


Clinical Trial BGB-A317-A1217-301

A Phase 3, Randomized, Open-Label Study to Compare Ociperlimab (BGB-A1217) Plus Tislelizumab (BGB-A317) Plus Concurrent Chemoradiation Followed by Ociperlimab Plus Tislelizumab or Tislelizumab Plus CCRT Followed by Tislelizumab Versus CCRT Followed by Durvalumab in Previously Untreated, Locally Advanced, Unresectable NSCLC

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04866017

ClinicalTrials.gov Link:

Click Here


Clinical Trial STRO-002-GM2

A Phase 1 Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of STRO-002, an Anti-Folate Receptor alpha Antibody Drug Conjugate (ADC), in Combination with Bevacizumab in Patients with Advanced Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers).

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03748186

ClinicalTrials.gov Link:

Click Here


Clinical Trial STK-012-101

A Phase 1a/1b Study to Evaluate the Safety and Tolerability of STK-012 Monotherapy and in Combination with Pembrolizumab in Subjects with Selected Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05098132

ClinicalTrials.gov Link:

Click Here


Clinical Trial M21-410

A Global First-in-Human Study in NSCLC, HNSCC and Solid Tumors with ABBV-514 as a Single Agent and in Combination with Pembrolizumab or Budigalimab

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05005403

ClinicalTrials.gov Link:

Click Here


Clinical Trial RLY-2608-101

A First-in-Human Study of Mutant-Selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination with Fulvestrant in Patients with Advanced Breast Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05216432

ClinicalTrials.gov Link:

Click Here


Clinical Trial RTX-224-01

A Phase 1/2 Study of RTX-224 for the Treatment of Patients with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05219578

ClinicalTrials.gov Link:

Click Here


Clinical Trial 516-010

A Two-Cohort, Two-Part, Phase 1, Multicenter, Open-Label, Fixed-Sequence, Drug-Drug Interaction with QTc Assessments of Sitravatinib Followed by Combination Treatment with Nivolumab in Patients with Advanced Solid Tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04887194

ClinicalTrials.gov Link:

Click Here


Clinical Trial BLU-701-1101

A Phase 1/2 Study of the Highly Selective EGFR Inhibitor, BLU-701, in Patients with EGFR-Mutant Non-Small Cell Lung Cancer.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05153408

ClinicalTrials.gov Link:

Click Here


Clinical Trial NBF-006

A Phase 1/1b Open-Label, Multi-Center, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics and Preliminary Efficacy of Intravenous NBF-006 in Patients with Non-Small Cell Lung, Pancreatic, or Colorectal Cancer Followed by a Dose Expansion Study in Patients with KRAS-Mutated Non-Small Cell Lung Cancer.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03819387

ClinicalTrials.gov Link:

Click Here


Clinical Trial SALA-002-EW16

A Phase I Trial of LSD1 Inhibitor Seclidemstat (SP-2577) with and without Topetecan and Cyclophosphamide in Patients with Relapsed or Refractory Ewing Sarcoma and Select Sarcomas

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03600649

ClinicalTrials.gov Link:

Click Here


Clinical Trial EFT226-0002

A Phase 1/2 Open Label, Sequential Group, Dose Escalation and Cohort Expansion Sutdy Evaluating the Safety, PK, PD and Antitumor Activity of eFT226 in Subjects with Selected Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04092673

ClinicalTrials.gov Link:

Click Here


Clinical Trial LOXO-RAS-20001

A Phase 1a/1b Study of LY3537982 in Patients with KRAS G12C-Mutated Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04956640

ClinicalTrials.gov Link:

Click Here


Clinical Trial MVR-T3011-003

A Phase 1/2a Open-Label Dose Escalation and Dose Expansion Study of T3011 when Administered via Intravenous Infusion as a Single Agent and in Combination with Pembrolizumab in Participants with Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04780217

ClinicalTrials.gov Link:

Click Here


Clinical Trial GO-007

A Screening Study for the Selection of Patients for Clinical Studies Targeting Tumor-Specific Antigens (Non-Interventional)

ClinicalTrials.gov ID:

NCT03953235

ClinicalTrials.gov Link:

Click Here


Clinical Trial VX15-2503-12

A Phase 1b/2 Study of the Combination of Pepinemab and Pembrolizumab in Patients with Advanced, Recurrent, or Metastatic Squamous Cell Cancer of the Head and Neck

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT 04815720

ClinicalTrials.gov Link:

Click Here


Clinical Trial TPX-0005-13

A Phase 1B/2 Study of Repotrectinib in Combination with Other Anticancer Therapies for the Treatment of Subjects with KRAS Mutated Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05071183

ClinicalTrials.gov Link:

Click Here


Clinical Trial FW-2020-1

A Phase 1/2 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CM24 in combination with nivolumab in adults with advanced solid tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04731467


Clinical Trial KZR-261-101

A Phase 1 Study of KZR-261, a Small Molecule Sec61 Inhibitor, in Subjects with Advanced Solid Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05047536

ClinicalTrials.gov Link:

Click Here


Clinical Trial ERAS-007-03

Phase 1b/2 Study of Agents Targeting the Mitogen Activated Protein Kinase Pathway in Patients with Advanced GI Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT05039177

ClinicalTrials.gov Link:

Click Here


Clinical Trial USOR 21400

A Phase 2 Clinical Study of TJ004309 in Combination with Atezolizumab in Patients with Advanced or Mets Ovarian Cancer and Selected Advanced Solid Tumors.

ClinicalTrials.gov ID:

NCT05001347

ClinicalTrials.gov Link:

Click Here


Clinical Trial MRG004A-001

“An Open-Label, Multi-center, Phase I/II Dose Escalation and Expansion Study to Assess
the Safety, Tolerability, Anti-Tumor Activity and Pharmacokinetics of MRG004A in
Patients with Tissue Factor Positive Advanced or Metastatic Solid Tumors”

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04843709

ClinicalTrials.gov Link:

Click Here


Clinical Trial AVB500-PC-005

A Phase 1b/2 Randomized Study of AVB-S6-500 plus Nabpaclitaxel
and Gemcitabine in Patients with Locally Advanced
or Metastatic Pancreatic Adenocarcinoma

Locations:

Fairfax Office

ClinicalTrials.gov ID:

  NCT04983407

ClinicalTrials.gov Link:

Click Here


Clinical Trial C4401001

A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY EVALUATING THE
SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS,
AND ANTITUMOR ACTIVITY OF PF-07257876 IN PATIENTS WITH ADVANCED
OR METASTATIC TUMORS

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04881045

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20291

A Phase 1b/2,  Master Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 510 (pINN Sotorasib) in Subjects with Advanced Solid Tumors with KRAS G12C Mutation                                         **MANY SUBPROTOCOLS FOR THIS TRIAL**

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20289

A Phase I Study of SEA-TGT (SGN-TGT) in Subjects with Advanced Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04254107

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20305

An Open-Label, Phase 1b, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics and Efficacy of the Aryl Hydocarbon Receptor Inhibitor (AhRi) BAY 2416964 in Combination with Pembrolizumab in Participants with Advanced Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04999202

ClinicalTrials.gov Link:

Click Here


Clinical Trial 18020

A Phase 1/2 Study of BMS-986253 in Combination with Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03400332

ClinicalTrials.gov Link:

Click Here


Clinical Trial TWT-101

A First in Human, Phase 1/2 Study of CFI-402411, Hematopoeitic Progenitor Kinase-1 (HPK1) Inhibitor, as a Single Agent and in Combination with Pembrolizumab in Subjects with Advnanced Solid Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04521413

ClinicalTrials.gov Link:

Click Here


Clinical Trial TTX-030-002

A Phase 1/1b Study to Evaluate the Safety and Activity of TTX-030 (Anti-CD39) in Combination with Pembrolizumab or Budigalimab and/or Chemotherapy in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04306900

ClinicalTrials.gov Link:

Click Here


Clinical Trial TPX-0022-01

A Phase I, Open-Label, Multicenter, First in Human Study of the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of TPX-0022, A Novel MET/CSF1R/SRC Inhibitor, in Patients with Advanced Solid Tumors Harboring Genetic Alterations I MET

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03993873

ClinicalTrials.gov Link:

Click Here


Clinical Trial RTX-24-01

Open-Label, Multicenter, First in Human Phase 1/2 Study of RTX-240 for the Treatment of Patients with Relapsed/Refractory or Locally Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04372706

ClinicalTrials.gov Link:

Click Here


Clinical Trial PEN-866-001

A Phase 1/2a, Open-Label, Mutlicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-Tumor Activity of PEN-866 in Patients with Advanced Solidy Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03221400

ClinicalTrials.gov Link:

Click Here


Clinical Trial DF6002-001

A Phase 1/2, First in Human, Multi-Part, Open-Label, Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF6002 as a Monotherapy and in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04423029

ClinicalTrials.gov Link:

Click Here


Clinical Trial TPX-0046-01

A Phase 1/2 Study of TPX-0046, A Novel Oral RET/SRC Inhibitor in Adult Subjects with Advanced/Metastatic Solid Tumors Harboring Oncogenic RET Fusions or Mutations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04161391

ClinicalTrials.gov Link:

Click Here


Clinical Trial ORIC-101-18101

An Open-Label Phase 1b Study of ORIC-101 in Combination with Anticancer Therapy in Patients with Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03928314

ClinicalTrials.gov Link:

Click Here


Clinical Trial M19-037

A Phase I, Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Combinations of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Subjects with Locally Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03893955

ClinicalTrials.gov Link:

Click Here


Clinical Trial NB-ND021 (NM21-1480)-101

Phase 1/2 Study of NM21-1480 (Anti-PD-L1/Anti-4-1BB/Anti-HAS Tri-Specific Antibody) in Adults with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04442126

ClinicalTrials.gov Link:

Click Here


Clinical Trial JAB-3312-1003

A Phase 1/2a, Multi-center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB3312 in Combination with Pembrolizumab or Binimetinib in Adults with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04720976

ClinicalTrials.gov Link:

Click Here


Clinical Trial I-MAB

A Phase I Study of TJ210001 Administered in Subjects with Relapsed or Refractory Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04678921

ClinicalTrials.gov Link:

Click Here


Clinical Trial CPO-100-US-101

A Phase I, Multicenter, Single Agent Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of CPO-100 in Adults with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

  NCT04931823

ClinicalTrials.gov Link:

Click Here


Clinical Trial D976MC00001

A Phase 2, Multicenter, Open-Label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Unresectable and or Mets Solid Tumors Harboring HER2 Activating Mutations Regardless of Tumor Histology

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04639219

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20383

A Phase 1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib in Combination with Everolimus in Subjects with Advanced Solid Tumors with KRAS G12C Mutation

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

Click Here


Clinical Trial KN 8701

A Phase 1/1b Open-Label, Multicenter, Two-Part Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of KIN-8701 in Subjects with BRAF Mutation Positive Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04913285

ClinicalTrials.gov Link:

Click Here


Clinical Trial TCTLR-101

Phase 1/2, Open-Label, Dose Escalation and Dose Expansion Study of Transcon TLR7/8 Agonist Alone or in Combination with Pembrolizumab in Participants with Locally Advanced or Metastatic Solid Tumor Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04799054

ClinicalTrials.gov Link:

Click Here


Clinical Trial D6185C00001

An Open-Label, Multi-Drug, Biomarker-Directed, Multicenter Phase II Umbrella Study in Patients with NSCLC, Who Progressed on and Anti-PD-1/PD-L1 Containing Therapy

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03334617

ClinicalTrials.gov Link:

Click Here


Clinical Trial AB154CSP0002

A Phase II Study to Evaluate the Safety and Efficacy of AB122 Monotherapy, AB154 in Combination with AB122, and AB154 in Combination with AB122 and AB928 in Front-Line NSCLC

ClinicalTrials.gov ID:

NCT04262856

ClinicalTrials.gov Link:

Click Here


Clinical Trial BGB-A317-A1217-302

A Phase III, Randomized, Double-Blind Study of BGB-A1217, an Anti-TIGIT Antibody, in Combination with Tislelizumab Compared to Pembrolizumab in Patients with Previously Untreated, PD-L1 Selected, and Locally Advanced, Unresectable or Metastatic NSCLC

ClinicalTrials.gov ID:

NCT04746924

ClinicalTrials.gov Link:

Click Here


Clinical Trial D910MC00001

Phase III, Randomized, Multicenter, Double-Blind, Placebo-Controlled Study of Durvalumab for the Treatment of Stage II-III NSCLC Patients with Minimal Residual Disease Following Surgery and Curative Intent Therapy.

Locations:

Fairfax Office


Clinical Trial 20139

A Phase III, Randomized, Controlled, Multi-Center, 3 Arm Study of Neoadjuvant Osimertinib as Monotherapy or in Combination with Chemotherapy versus SOC Chemo Alone for the Treatment of Patients with EGFR Positive, Resectable NSCLC


Clinical Trial D910LC00001

A Phase III, Randomized, Multicenter, Double Blind, Placebo Controlled Study to Determine the Efficacy of Adjuvant Durvalumab in Combination with Platinum-Based Chemotherapy in Completely Resected Stage II-III NSCLC


Clinical Trial ACT16146

Randomized, Open-Label Phase II Study of SAR408701 Combined with Pembrolizumab and Pembrolizumab Alone in Patients with CEACAM5 and PD-L1 Positive Advanced/Metastatic Non-Squamous NSCLC.

ClinicalTrials.gov ID:

NCT04524689

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20270

Phase II Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced NSCLC with KRAS G12C Mutation

ClinicalTrials.gov ID:

NCT04613596

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20384

A Phase Ib Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG510 (pINN Sotorasib) in Combination with Carboplatin and Pemetrexed; with Docetaxel; or with Carboplatin and Paclitaxel in Subjects with Advanced NSCLC with KRAS G12C Mutation


Clinical Trial U31402-A-U103

A Phase I Open-Label Study of Patritumab Deruxtecan (U3-1402) in Combination with Osimertinib in Subjects with Locally Advanced or Mets EGFR-Mutated NSCLC

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04676477

ClinicalTrials.gov Link:

Click Here


Clinical Trial 61186372EDI1001

Phase I, First-in-Human, Open-Label, Dose Escalation Study of JNJ-61186372, a Human Bispecific EGFR and cMet Antibody, in Subjects with Advanced NSCLC

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT02609776

ClinicalTrials.gov Link:

Click Here


Clinical Trial TPX-0131-01

Phase I/II Study of TPX-0131, A Novel Oral ALK TKI in Subjects with ALK+ Advanced or Metastatic NSCLC

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04849273

ClinicalTrials.gov Link:

Click Here


Clinical Trial KL 264-01

A Phase I-II, First in Human Study of SKB264 in Patients with Locally Advanced Unresectable and Metastatic Solid Tumors Who Are Refractory to Available Standard Therapies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04152499

ClinicalTrials.gov Link:

Click Here


Clinical Trial 20414

An Open-Label Phase 1b/2 Study of Surufatinib in Combination with Tislelizumab in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04579757

ClinicalTrials.gov Link:

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Clinical Trial MRTX849-001

A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03785249

ClinicalTrials.gov Link:

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Clinical Trial PCS6422G1-01

A Phase 1b Dose-Escalation Study of the Safety and Pharmacokinetics of Fixed-Dose PCS6422 with Escalating Doses of Capecitabine Administered Orally to Patients with Advanced, Refractory Gastrointestinal Tract Tumors

ClinicalTrials.gov ID:

NCT04861987

ClinicalTrials.gov Link:

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Clinical Trial 20310

A Phase 1b Study Evaluating the Safety, Tolerability, and Efficacy of Sotorasib in Combination with Panitumumab and in Combination with Panitumumab and FOLFIRI in Subjects with Advanced Solid Tumors with KRAS G12C

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04185883

ClinicalTrials.gov Link:

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Clinical Trial 21194

A Phase 1b Study Evaluating the Safety, Tolerability, and Efficacy of Sotorasib in Combination with MVASI and FOLFIRI and in Combination with MVASI and FOLFOX in Subjects with Advanced Colorectal Cancer with KRAS G12C Mutation

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04190135


Clinical Trial DS1062-A-U301

Phase 3 Randomized Study of DS-1062A Versus Docetaxel in Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer Without Actionable Genomic Alterations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04656652

ClinicalTrials.gov Link:

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Clinical Trial 20344

A Phase 2 Basket Study of Tucatinib in Combination with Trastuzumab in Subjects with Previously Treated, Locally-Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04579380

ClinicalTrials.gov Link:

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Clinical Trial 20381

Molecularly Informed Lung Cancer Treatment in a Community Cancer Network: A Pragmatic Prospective RWE Study (MYLUNG Consortium: Part 2)


Clinical Trial 20331

A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) as a Single Agent and in Combination with Defactinib (FAK Inhibitor) in Recurrent KRAS-Mutant (KRAS-MT) Non-Small Cell Lung Cancer (NSCLC)

ClinicalTrials.gov ID:

NCT04620330

ClinicalTrials.gov Link:

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Clinical Trial 18194

A Phase 1 Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of STRO-002, an anti-Folate Receptor alpha (FolRá) Antibody Drug Conjugate (ADC), in Patients with Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal Cancers) and Endometrial Cancers

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03748186

ClinicalTrials.gov Link:

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Clinical Trial 20249

A Randomized, Open-label Phase 3 Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared with Carboplatin-Pemetrexed, in Patients with EGFR Exon 20ins Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (61186372NSC3001)

ClinicalTrials.gov ID:

NCT04538664

ClinicalTrials.gov Link:

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Clinical Trial CLN-081-001

A Phase 1/2a, Open-Label, Multi-Center Trial to Assess Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of CLN-081 in Patients with Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04036682

ClinicalTrials.gov Link:

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Clinical Trial ZWI-ZW49-101
Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03821233

ClinicalTrials.gov Link:

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Clinical Trial 73841937NSC1001

An Open-label Phase 1/1b Study to Evaluate the Safety and Pharmacokinetics of JNJ-73841937 (Lazertinib), a Third Generation EGFR-TKI, as Monotherapy or in Combinations With JNJ-61186372, a Human Bispecific EGFR and cMet Antibody in Participants With Advanced Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04077463

ClinicalTrials.gov Link:

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Clinical Trial 19211

A Phase III, Double-blind, Placebo-controlled, Multi-center International Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients with Resectable Stages II and III Non-small Cell Lung Cancer (AEGEAN) (D9106C00001)

ClinicalTrials.gov ID:

NCT03800134

ClinicalTrials.gov Link:

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Clinical Trial RTX-240-01

PHASE 1/2 STUDY OF RTX-240 MONOTHERAPY

Open label, multicenter, multidose, first-in-human Phase 1/2 study of RTX-240 for the treatment of patients with relapsed/refractory or locally advanced solid tumors.

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04372706

ClinicalTrials.gov Link:

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Clinical Trial 20137

A PHASE III, OPEN-LABEL, RANDOMIZED STUDY OF ATEZOLIZUMAB AND TIRAGOLUMAB COMPARED WITH DURVALUMAB IN PATIENTS WITH LOCALLY ADVANCED, UNRESECTABLE STAGE III NON-SMALL CELL LUNG CANCER WHO HAVE NOT PROGRESSED AFTER CONCURRENT PLATINUM-BASED CHEMORADIATION (SKYSCRAPER-03)

ClinicalTrials.gov ID:

NCT04513925

ClinicalTrials.gov Link:

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Clinical Trial M19-611

A Phase 1b Efficacy and Safety Study of Cofetuzumab Pelidotin (ABBV-647, a PTK7-Targeting Antibody Drug Conjugate) in Subjects with PTK7-Expressing, Recurrent Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04189614

ClinicalTrials.gov Link:

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Clinical Trial APG-115-US-002
Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03611868

ClinicalTrials.gov Link:

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Clinical Trial KL26401

A Phase I-II, First-in-Human Study of SKB264 in Patients with Locally Advanced Unresectable /Metastatic Solid Tumors who are refractory to Available Standard Therapies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT04152499

ClinicalTrials.gov Link:

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Clinical Trial 19043

A Phase 2 Open Label Study of Sacituzumab Govitecan (IMMU-132) in Subjects with Metastatic Solid Tumors (IMMU-132-11)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03964727

ClinicalTrials.gov Link:

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Clinical Trial 19082

A PHASE 1/1B MULTICENTER STUDY TO EVALUATE THE HUMANIZED ANTI-CD73 ANTIBODY, CPI-006, AS A SINGLE AGENT OR IN COMBINATION WITH CIFORADENANT, WITH PEMBROLIZUMAB, AND WITH CIFORADENANT PLUS PEMBROLIZUMAB IN ADULT SUBJECTS WITH ADVANCED CANCERS (CPI-006-001)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03454451

ClinicalTrials.gov Link:

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Clinical Trial TPX-005-001

A Phase 1/2, Open-Label, Multi-Center, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Anti-Tumor Activity of TPX-0005 in Patients with Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements (TRIDENT-1)

ClinicalTrials.gov ID:

NCT03093116

ClinicalTrials.gov Link:

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Clinical Trial PSB205

A Phase 1, Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumor Activity of PSB205 in Patients with Relapsed/ Refractory Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03986606

ClinicalTrials.gov Link:

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Clinical Trial ASTX295-01

Phase 1/2 Open-Label Study of the Safety, Pharmacokinetics, and Preliminary Activity of ASTX295 in Subjects with Wild-Type TP53 Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03975387

ClinicalTrials.gov Link:

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Clinical Trial 849-001

A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03785249

ClinicalTrials.gov Link:

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Clinical Trial 14059

Phase I/II trial of Ibrutinib plus Trastuzumab in HER2-amplified Metastatic Breast Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT3379428


Clinical Trial 101-18101

An Open-label Phase 1b Study of ORIC-101 in Combination with Anticancer Therapy in Patients with Advanced or Metastatic Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03928314

ClinicalTrials.gov Link:

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Clinical Trial GO-005

A Phase 1/2 Study of GRT-C903/GRT-R904, a Vaccine Targeting Shared Neoantigens, in Combination with Immune Checkpoint Blockade for Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03953235

ClinicalTrials.gov Link:

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Clinical Trial M14-239

Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects with Previously Treated c-Met+ Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03539536

ClinicalTrials.gov Link:

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Clinical Trial C2321001

A PHASE I DOSE ESCALATION AND EXPANDED COHORT STUDY OF PF-06821497 IN THE TREATMENT OF ADULT PATIENTS WITH RELAPSED/REFRACTORY SMALL CELL LUNG CANCER (SCLC), CASTRATION RESISTANT PROSTATE CANCER (CRPC) AND FOLLICULAR LYMPHOMA (FL)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03460977

ClinicalTrials.gov Link:

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Clinical Trial LOXO-RET-17001

A Phase 1/2 Study of Oral LOXO-292 in Patients with Advanced Solid Tumors, Including RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors with RET Activation (LIBRETTO-001

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03157128

ClinicalTrials.gov Link:

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Clinical Trial CP-MGC018-01

A Phase 1/2, First-in-Human, Open-Label, Dose-Escalation Study of MGC018 (Anti–B7-H3 Antibody Drug Conjugate) Alone and in Combination with MGA012 (Anti–PD-1 Antibody) in Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03729596

ClinicalTrials.gov Link:

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Clinical Trial AO-176-101

A Phase 1 Multicenter, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AO-176

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03834948

ClinicalTrials.gov Link:

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Clinical Trial GO-004

An International Phase 1/2 Study of GRT-C901/GRT-R902, a Neoantigen Cancer Vaccine, in Combination with Immune Checkpoint Blockade for Patients with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03639714

ClinicalTrials.gov Link:

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Clinical Trial Janssen 61186372EDI10051

A Phase 1, First-in-Human, Open-Label, Dose Escalation Study of JNJ-61186372, a Human Bispecific EGFR and cMet Antibody, in Subjects with Advanced Non-Small Cell Lung Cancer

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT02609776

ClinicalTrials.gov Link:

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Clinical Trial GO-003

An Observational Feasibility Study for the Production of a Patient-Specific Neoantigen Cancer Vaccine in Patients with Advanced Cancer

Locations:

Fairfax Office


Clinical Trial 17-167

A phase III, multicenter, randomized, double blind, placebo-controlled study evaluating the efficacy and safety of canakinumab versus placebo as adjuvant therapy in adult subjects with stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) completely resected (R0) non-small cell lung cancer (NSCLC)(CACZ885T2301)

ClinicalTrials.gov ID:

NCT03447769

ClinicalTrials.gov Link:

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Clinical Trial CTMX-M-2029-001

A Phase 1-2, First-in-Human Study of CX-2029 in Adults with Metastatic or Locally Advanced Unresectable Solid Tumors or Diffuse Large B-cell Lymphomas (PROCLAIM-CX-2029)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03543813

ClinicalTrials.gov Link:

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Clinical Trial 18-020

A Phase 1/2a Study of BMS-986253 in Combination with Nivolumab in Advanced Cancers (CA027002)

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03400332

ClinicalTrials.gov Link:

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Clinical Trial Astex ASTX029

Study of ASTX029 in Subjects With Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03520075

ClinicalTrials.gov Link:

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Clinical Trial STRO-001-BCM1

Study of STRO-001, an Anti-CD74 Antibody Drug Conjugate, in Patients With Advanced B-Cell Malignancies

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03424603

ClinicalTrials.gov Link:

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Clinical Trial DS1062-A-J101

First-in-human Study of DS-1062a for Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03401385

ClinicalTrials.gov Link:

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Clinical Trial Tesaro 4020-01-001

A Phase 1 Study of TSR-022, an Anti-TIM-3 Monoclonal Antibody, in Patients With Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT02817633

ClinicalTrials.gov Link:

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Clinical Trial R3767-ONC-1613

Study of REGN3767 (Anti-LAG-3) With or Without REGN2810 (Anti-PD1) in Advanced Cancers

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT03005782

ClinicalTrials.gov Link:

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Clinical Trial M14-237

A Multicenter, Phase 1/1b, Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects with Advanced Solid Tumors

Locations:

Fairfax Office

ClinicalTrials.gov ID:

NCT02099058

ClinicalTrials.gov Link:

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