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Supplements and Cancer: What You Need to Know Now

April 23, 2019

Earlier this month, a study was published by Tuft’s University researchers in the Annals of Internal Medicine.  It looked at a large government database of Americans, focusing on vitamins and mineral intake from food and supplements, and outcomes such as cancer, cardiovascular disease, and death.

As a Virginia Cancer Specialists dietitian, supplement questions are on our frequently asked list.  The good news?  Patients are more informed than ever and taking charge of dietary changes that can decrease cancer risk and increase survivorship.  The downside?  There’s much misinformation out there and each patient needs to be considered as an individual with respect to cancer site, nutrient status, lifestyle, and recommendations for getting adequate nutrients. And this can be confusing when you are navigating information on the Internet.

What does this study show?

First, supplement use remains high in our country.  The study authors showed that more than half of individuals reported use of dietary supplements overall, and close to 4 out of 10 had used multivitamin and mineral supplements, in the previous 30 days.  The most commonly used vitamin supplements included vitamin C, vitamin E, and vitamin D.  The most common mineral supplements included calcium, zinc, and magnesium. How does supplementation match up with intake?  The study found that more than half of all surveyed had inadequate intake of vitamin D, vitamin E, choline, vitamin K, and potassium.

Bottom line: what do you need to know?

The only supplement that demonstrated promise in reducing risk of dying from cancer and cardiovascular disease was lycopene (the nutrient that is often associated with tomatoes).

Taking high doses of calcium supplements appears to increase the risk of dying from cancer. Note that this relationship is not seen when consuming foods with calcium.

High doses of vitamin D supplements is associated with increased risk of death and cancer.  Note that this does not apply to those who have vitamin D deficiency.

Our advice?  When in doubt, do not begin supplementing on your own without talking to your doctor or dietitian.

See:  Medscape article Dietary Supplements Have No Effect on Mortality Risk for additional study details and a Virginia Cancer Specialists RD if you have questions about your own nutrient needs.

Vitamins supplements as a capsule with fruit vegetables nuts and beans inside a nutrient pill as a natural medicine health treatment with 3D illust...

Vitamins supplements as a capsule with fruit vegetables nuts and beans inside a nutrient pill as a natural medicine health treatment with 3D illust...

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About Virginia Cancer Specialists

Virginia Cancer Specialists, the largest private cancer practice in Northern Virginia, was recognized in 2024 and 2025 as the #1 physician practice in Virginia with the most Castle Connolly top doctors in cancer care and across all medical specialties. It features a world-class treatment team fighting cancer and diseases of the blood, offering access to the most current treatment protocols, clinical trials, and comprehensive care. Its fully staffed, comprehensive clinical research program also includes a dedicated research facility for Phase I clinical trials—the Virginia Cancer Specialists Research Institute, the largest of its kind in the Mid-Atlantic region. The practice offers medical oncology, radiation oncology, musculoskeletal tumor surgery, breast surgery, thoracic surgery, genetic counseling, palliative care, oncology nurse navigators, oncology infusion nurses, oncology pharmacists, social workers, dietitians, and laboratory technicians. Virginia Cancer Specialists is part of The US Oncology Network. This collaboration unites the practice with more than 1,400 independent physicians and research and data from thousands of cancer patients in clinical trials across the country. Virginia Cancer Specialists also participates in clinical trials through US Oncology Research, which has played a role in more than 100 FDA-approved cancer therapies. For more information, visit USOncology.com. For more information about Virginia Cancer Specialists, visit: VirginiaCancerSpecialists.com

The Network is supported by McKesson Corporation, a global leader in healthcare solutions.

SOURCE Virginia Cancer Specialist

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