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An implant containing a sustained release particle of fluorouracil, an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine, with antineoplastic activity. Upon implantation and subsequent release, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with the pyrimidine uracil during RNA synthesis while another active metabolite, 5-5-fluoro-2′-deoxyuridine-5′-O-monophosphate, inhibits thymidylate synthase and thus DNA synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)
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