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MMRC MyDrug Clinical Trial - Myeloma-Developing Regimens Using Genomics

Virginia Cancer Specialists Practice Blog

June 26, 2019
Virginia Cancer Specialists » VCS Practice News » Clinical Trials and Research » VCS Practice News » Clinical Trials Search » MMRC MyDrug Clinical Trial – Myeloma-Developing Regimens Using Genomics

The MMRC MyDRUG trial represents the pinnacle of precision medicine in myeloma. It is the culmination of MMRF precision medicine efforts dating back to 2004, when the MMRF formed the first tissue bank in myeloma to provide this resource to researchers. MMRF was the first to sequence the myeloma genome; this resulted in the discovery of the first actionable mutations in myeloma. Our observational, longitudinal CoMMpass Study was launched to confirm those actionable mutations and discover more of them; as a result of these efforts, 12 myeloma genomic subtypes have been identified so far.

MyDRUG is the first platform trial in myeloma and it grew out of the actionable mutations found in CoMMpass. MMRF has spearheaded this effort from investment ($12M), to pharma partner recruitment, to clinical center identification and start-up. The team includes 6 pharma partners, and 17 MMRC academic centers. Patients will undergo genomic screening for actionable mutations, and will be treated with an oral standard of care regimen (Ninlaro, Pomalyst, and dex) plus the appropriate targeted agent. The targeted agents include therapies that are approved for use in other cancer indications, and are only available to myeloma patients enrolled in this trial. Patients with no actionable alterations will be treated with the standard of care plus an immunotherapeutic agent. Arms may be added to the trial as new targeted agents become available, or removed if the agents are found to be ineffective.

To learn more about this Clinical Trial – visit the Trial Link at Virginia Cancer Specialists Here

Principle Investigator:

Harold C. Agbahiwe, MD Headshot

Harold C. Agbahiwe, MD

Radiation Oncologist

Stephanie Akbari, MD, FACS Headshot

Stephanie Akbari, MD, FACS

Breast Surgeon

Ivan Aksentijevich, MD Headshot

Ivan Aksentijevich, MD

Medical Oncologist

Christina Brzezniak, DO Headshot

Christina Brzezniak, DO

Medical Oncologist

Daniel Chong, MD Headshot

Daniel Chong, MD

Medical Oncologist

Robert Christie, MD, FACP Headshot

Robert Christie, MD, FACP

Medical Oncologist

Igryl S. Cordero, MD Headshot

Igryl S. Cordero, MD

Medical Oncologist

Ajay Dar, MD Headshot

Ajay Dar, MD

Medical Oncologist

Samantha DiBenedetto, MD Headshot

Samantha DiBenedetto, MD

Medical Oncologist

Kevin Diasti, MD, MBA Headshot

Kevin Diasti, MD, MBA

Medical Oncologist

Anne Favret, MD Headshot

Anne Favret, MD

Medical Oncologist

John Feigert, MD Headshot

John Feigert, MD

Medical Oncologist

Elizabeth Feldman, MD, FACS Headshot

Elizabeth Feldman, MD, FACS

Breast Surgeon

Mitul Gandhi, MD Headshot

Mitul Gandhi, MD

Medical Oncologist

Jessica Heintz, MD, FAAHPM Headshot

Jessica Heintz, MD, FAAHPM

Supportive Cancer Care Physician

Alina M. Huang, MD Headshot

Alina M. Huang, MD

Medical Oncologist

Matthew T. Hueman, MD, FACS, FSSO Headshot

Matthew T. Hueman, MD, FACS, FSSO

Breast Surgeon

Danijela Jelovac, MD Headshot

Danijela Jelovac, MD

Medical Oncologist

Christopher R. Johnson, MD Headshot

Christopher R. Johnson, MD

Thoracic Surgeon

Sandeep J. Khandhar, MD, FACS Headshot

Sandeep J. Khandhar, MD, FACS

Thoracic Surgeon

Isabelle Le, MD Headshot

Isabelle Le, MD

Medical Oncologist

Samuel Lee, MD Headshot

Samuel Lee, MD

Medical Oncologist

Jey A. Maran, MD Headshot

Jey A. Maran, MD

Medical Oncologist

Robert L. Marsh, MD Headshot

Robert L. Marsh, MD

Medical Oncologist

Timothy A. McCarthy, MD Headshot

Timothy A. McCarthy, MD

Medical Oncologist

Geoffrey D. Moorer, MD Headshot

Geoffrey D. Moorer, MD

Medical Oncologist

Jacob A. Ninan, MD Headshot

Jacob A. Ninan, MD

Medical Oncologist

Dipti Patel-Donnelly, MD Headshot

Dipti Patel-Donnelly, MD

Medical Oncologist

Lindy Rosal, MD, FACS Headshot

Lindy Rosal, MD, FACS

Breast Surgeon

M. Adham Salkeni, MD, FRCPC Headshot

M. Adham Salkeni, MD, FRCPC

Medical Oncologist, Virginia Cancer Specialists Research Institute

Keeran R. Sampat, MD Headshot

Keeran R. Sampat, MD

Medical Oncologist

Amit Sarma, MD Headshot

Amit Sarma, MD

Medical Oncologist

Gregory S. Sibley, MD Headshot

Gregory S. Sibley, MD

Radiation Oncologist

Muhammad Siddiqui, MD Headshot

Muhammad Siddiqui, MD

Supportive Cancer Care Physician

Anmol Singh, MD Headshot

Anmol Singh, MD

Medical Oncologist

Alexander I Spira MD, PhD, FACP, FASCO Headshot

Alexander I Spira MD, PhD, FACP, FASCO

Medical Oncologist

Tejas Suresh, MD Headshot

Tejas Suresh, MD

Medical Oncologist

Shruti Tiwari, MD Headshot

Shruti Tiwari, MD

Medical Oncologist

Hernan Vargas, MD, FACS Headshot

Hernan Vargas, MD, FACS

Breast Surgeon

David Weintritt, MD, FACS Headshot

David Weintritt, MD, FACS

Breast Surgeon

Felasfa M. Wodajo, MD Headshot

Felasfa M. Wodajo, MD

Musculoskeletal Tumor Surgeon

Chao Yin, MD Headshot

Chao Yin, MD

Medical Oncologist

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